Docente di Farmacologia

Antonella Scorziello holds a degree in Medicine and Surgery, a Specialist in Pharmacology, a PhD in Neuropsychopharmacology and Toxicology, and a full professor of Pharmacology at the University of Naples Federico II. His research activity is mainly oriented towards the study of the cellular and molecular mechanisms underlying neurodegenerative diseases with particular reference to the role of mitochondria in regulating cellular ion homeostasis. Specifically, it helped clarify the role of oxidative stress in cellular and animal models of hypoxia/reoxygenation, Parkinson's disease, and Alzheimer's disease, demonstrating that reactive oxygen species produced during stress are able to modulate the activity of the sodium calcium exchanger NCX as well as proteins involved in iron metabolism at both the transcriptional and post-transcriptional levels. In 2004 he attended the Mitochondrial Biology Group at University College London, directed by Prof. Michael Duchen, as a visiting scientist, deepening the study of mitochondrial function with confocal microscopy approaches. Over the past fifteen years, his research has focused on the study of mitochondrial dysfunction in cerebral ischemia and Parkinson's disease, with particular attention to the role played by the sodium calcium exchanger in regulating mitochondrial ion homeostasis and in the mechanisms controlling mitochondrial dynamics.
Antonella Scorziello has a degree in Medicine and Surgery. In this context, she demonstrated that isoform 3 of the NCX exchanger is localized on the outer mitochondrial membrane where it colocalizes with the PKA anchoring protein, AKAP121, and contributes to the regulation of calcium efflux from the intermembrane space under both normoxic and hypoxic conditions, promoting cell survival. She collaborates with national and international research groups, is the author of approximately 90 publications in international scientific journals and several book chapters related to pharmacology and neuroscience. E’ holder of two patents on the use of drugs active in cerebral ischemia and neurodegenerative diseases. It is responsible for research activity and training within Research Projects obtained on the basis of competitive calls funded by public bodies such as the Ministry of Research, the Campania region, in the field of neurodegenerative diseases with particular interest in Parkinson's disease and cerebral ischemia. He is currently a member of the Animal Welfare Body (OPBA) and coordinator of the School of Specialization in Pharmacology and Clinical Toxicology.
In this context, it demonstrated that NCX exchanger isoform 3 is localized on the outer mitochondrial membrane where it colocalizes with the PKA anchoring protein, AKAP121 and contributes to the regulation of calcium efflux from the intermembrane space under both normoxic and hypoxic conditions by promoting cell survival.