RTDa

Sara La Manna is a Time-Determined Researcher - Type A (CHEM-03/A general and inorganic chemistry), at the University of Naples Federico II, Department of Pharmacy. She graduated with honors in Pharmaceutical Chemistry and Technology from the University of Naples Federico II, Department of Pharmacy, in 2016. He received his PhD in Pharmaceutical Sciences on May 20, 2020. Doctoral thesis in Italian-Spanish co-authorship between the University of Naples Federico II and the Autonomous University of Madrid (ES) entitled "Protein dissection approach as a powerful tool for identifying new potential drugs". In February 2020, he won a three-year scholarship as Principal Investigator (PI) for Italy-Cancer Research (FIRC)-Italian Association for Cancer Research (AIRC) (from February 2020 to January 2023) at the University of Naples Federico II. In 02/2023 he won the Umberto Veronesi Foundation 2023 Post-Doctoral Scholarships as PI (from 02/2023 to 07/2024). She is currently involved as a team member in the following national project: 2023-2028: AIRC- Inventor Grant (IG). Title: "Regulation of the JAK-STAT pathway by SOCS proteins in cancer: SOCS mimetics as anticancer therapeutics." PI: Prof. Daniela Marasco. Sara La Manna's scientific activity, carried out at the Department of Pharmacy of the University of Naples Federico II, concerns the chemistry of peptides and proteins, in their functionalization and chemical modification, associated with thermodynamic and kinetic characterizations, through in vitro binding assays (surface plasmon resonance (SPR), biolayer interferometry (BLI), fluorescence and microscale thermophoresis (mst)) and structural investigations by circular dichroism (cd) and nuclear magnetic resonance (nmr) spectroscopies. Ability to perform, analyze, and interpret cellular experiments thanks to a good knowledge of primary vascular smooth muscle cell (VSMC) cultures and Western blot, RT-PCR, and immunofluorescence techniques.