11.2022 - 02.2026

STROKEMARK

The STROKEMARK project plans to enroll approximately 100 consecutive patients 

(aged 18–90 years) with acute ischemic stroke treated with thrombolysis at the IRCCS Policlinico San Martino in Genoa. 

Clinical and demographic data, cardiovascular risk factors, and comorbidities are collected upon admission and 

discharge. Laboratory analyses include renal, hepatic, metabolic, and inflammatory parameters, performed at baseline, 

on day 1, day 7, and day 90. 

Radiological assessments (CT, CT angiography, perfusion CT) analyze vessel reopening (recanalization), 

reperfusion, ischemic core and penumbra, as well as hemorrhagic transformation. 

Neurological outcomes are measured using NIHSS and mRS at admission, discharge, and 90 days, supplemented by 

neuropsychological tests (MoCA, MMSE) and delirium assessment (4AT). Functional recovery and rehabilitation are 

monitored for up to one year. 

The aim of the study is to correlate clinical, imaging, and biomolecular data with short- and long-term neurological outcomes
The STROKEMARK study has potential applications in both 

clinical practice and translational research. By integrating clinical, biochemical, and radiological data with inflammatory biomarkers 

and aging genes, the project aims to identify reliable predictors of short- and long-term outcomes 

in patients with ischemic stroke treated with thrombolysis. 

These predictors could enable risk stratification to identify patients with a higher probability of 

unfavorable functional recovery, hemorrhagic transformation, or post-ictal delirium, supporting personalized therapeutic and 

rehabilitation strategies. 

In addition, the identification of new molecular pathways may offer innovative drug targets, improving 

patient selection for reperfusion therapies and allowing for the personalization of follow-up programs. 

The biobank and data platform generated by the study will be a valuable resource for future multicenter collaborations,

 promoting innovation in stroke management, reducing disability, and optimizing the use

of healthcare resources in an ever-growing elderly population.

Settori Scientifico Disciplinari

MED/09  INTERNAL MEDICINE

Spoke 6 : Neurodegeneration, Trauma and Stroke