11.2022 - 02.2026

Cognitive plasticity in fish models

The project investigates the mechanisms underlying cognitive plasticity in fish, integrating molecular, developmental, and behavioral perspectives. We focus on two major pathways: the role of brain-derived neurotrophic factor (BDNF) in shaping neural and behavioral variability, and the influence of the stress axis on cognition through cortisol and its receptors. By combining mutant models with natural genetic variation, we aim to uncover how differences in gene expression translate into behavioral traits such as learning, flexibility, and anxiety. In parallel, we explore how environmental experiences enhance cognitive performance, highlighting the remarkable plasticity of the fish brain. Overall, the project seeks to identify the molecular, physiological, and ecological mechanisms through which cognition is modulated, providing a comparative framework to better understand how animals adjust their cognitive abilities to environmental challenges.

By examining the roles of BDNF and the stress axis in shaping learning, memory, and flexibility, we establish fish as tractable models for uncovering conserved mechanisms of brain plasticity. Because these pathways are highly conserved across vertebrates, our findings may provide insights into the biological underpinnings of cognitive decline, mood disorders, and stress-related pathologies in humans. In particular, understanding how genes and environmental factors interact to regulate neuronal activity can inform the development of therapeutic strategies targeting neurodegeneration, depression, anxiety, and cognitive impairment. Fish models thus represent a powerful translational tool, bridging basic neurobiology with biomedical applications and opening avenues for novel interventions that promote resilience and cognitive health.

Settori Scientifico Disciplinari

BIO/05  ZOOLOGY

Spoke 4 : Perception and Brain-Body Interaction